|
KMID : 0861020100250010055
|
|
Korea Journal of Herbology
2010 Volume.25 No. 1 p.55 ~ p.63
|
|
|
Inhibitory Effect of a Decoction of Eucommiae ulmidesOLIVER and Dipsacus asperoides C. Y. Cheng et T.M.Ai on Collagen 2-induced Arthritis Mice
|
|
Lee Boo-Kyun
Lee Young-Cheol
Lee Jang-Cheon
|
|
|
Abstract
|
|
|
Objectives: The object of this study was to verify the inhibitory effect of a decoction of Eucommiae ulmides OLIVER (EU) and Dipsacus asperoides C. Y. Cheng et T.M.Ai (DA) on Collagen II-induced Arthritis Mice (CIA mice).
Methods: DBA/1OlaHsd mice were immunized with bovine type II collagen. Boostnig same collagen 21 days later, arthritis was induced and then administrated orally the extract of EU+DA (200 or 50 mg/kg) once a day for 4 weeks and compared with that of methotrexate (MTX, 0.3 mg/kg) as a positive control.
Results: Administration of EU+DA suppressed the inflammatory progression of CIA mice and the results were
1. Arthritis index of CIA mice was decreased 2. EU+DA decreased the production of TNF-α, IL-6, IL-1β in the serum of CIA mice. 3. EU+DA decreased the level of IgM. 4. EU+DAincreasaed CD3?, CD4?, CD4?/CD25 but decreased CD19?, CD3?/CD49b?(NKT), CD3?/CD49b? (NK), B220?/CD23? in PBMC of CIA mice. 5. EU+DA decreased CD3?, CD4?, CD3?/CD69? of paw joint in CIA mice. 6. EU+DA decreased subsynovial inflammation.
Conclusions: This results demonstrated that extract of EU+DA suppressed the inflammatory progression of CIA mice and supported further studies are required to clarify a mechanism of therapeutic role.
|
|
|
KEYWORD
|
|
|
Eucommiae ulmides OLIVER, Dipsacus asperoides C. Y. Cheng et T.M.Ai, arthritis, CIA Mice model
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|